Computer-aided discovery and biological characterization of human lactate dehydrogenase 5 inhibitors with anti-osteosarcoma activity.

Wei Cao,Le Fang,Siyong Teng,Hongwei Chen,Zhan Wang

Bioorganic & Medicinal Chemistry Letters（2018）

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摘要

•Compound 9 displayed a potent anti-hLDH5 activity with an EC50 value of 0.39 µM.•Compound 9 strongly inhibited MG-63 cell growth with an IC50 value of 3.18 µM.•Compound 9 decreased the lactate formation in MG-63 cancer cell.

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关键词

Cancer metabolism,Anticancer drug,Metabolic reprogramming,Virtual screening,Proliferation

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