Cannabinoid receptor type 1 in the brain regulates the affective component of visceral pain in mice.

Danica Bajic,Krisztina Monory,Andrea Conrad, Christina Maul,Roland M Schmid,Carsten T Wotjak,Christoph K Stein-Thoeringer

Neuroscience（2018）

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摘要

•CB1 deletion in cortical glutamatergic neurons revealed a major role of supraspinal CB1 in acute visceral nociception.•Supraspinal CB1 predominantly modulates the affective component of visceral pain.•CB1 has divergent roles in nociception depending on the nature of pain, e.g., heat vs. visceral nociceptive stimulus.

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关键词

ACC,ACT,AEA,CB1,CB1,CNS,HPT,ISH,KO,MGS,MGS,mPFC,THC,TRPV1,WT

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