Anticoagulation and Antiplatelet Strategies After On-X Mechanical Aortic Valve Replacement.

John D Puskas,Marc Gerdisch,Dennis Nichols,Lilibeth Fermin,Birger Rhenman, Divya Kapoor,Jack Copeland,Reed Quinn,G Chad Hughes,Hormoz Azar,Michael McGrath,Michael Wait,Bobby Kong,Tomas Martin, E Charles Douville,Steven Meyer,Jian Ye,W R Eric Jamieson, Lance Landvater,Robert Hagberg, Timothy Trotter, John Armitage, Jeffrey Askew,Kevin Accola, Paul Levy,David Duncan, Bobby Yanagawa, John Ely,Allen Graeve

Journal of the American College of Cardiology（2018）

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摘要

DAPT was associated with higher rates of thromboembolism and valve thrombosis compared with control in the low-risk arm. International normalized ratios were safely maintained at 1.5 to 2.0 in high-risk patients, without differences in mortality or thromboembolic complications. (Randomized On-X Anticoagulation Trial [PROACT]; NCT00291525).

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关键词

anticoagulation,dual-antiplatelet therapy,mechanical aortic valve replacement,thromboembolism

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