Continuous Interdomain Orientation Distributions Reveal Components of Binding Thermodynamics

Journal of Molecular Biology, pp. 3412-3426, 2018.

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Abstract:

The flexibility of biological macromolecules is an important structural determinant of function. Unfortunately, the correlations between different motional modes are poorly captured by discrete ensemble representations. Here, we present new ways to both represent and visualize correlated interdomain motions. Interdomain motions are determ...More

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