Neuroprotective effects of INT-777 against Aβ 1-42 -induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice.

•INT-777 ameliorates cognitive impairment induced by intracerebroventricular injection of Aβ1–42 in mice.•INT-777 attenuates Aβ1–42-induced neuroinflammation, apoptosis, and synaptic dysfunction in mice.•INT-777 reverses Aβ1–42-induced TGR5 down-regulation in the hippocampus and frontal cortex.