Synthesis and characterization of amino acid substituted sunitinib analogues for the treatment of AML.

Zoltán Nemes,Krisztina Takács-Novák,Gergely Völgyi,Klara Valko,Szabolcs Béni,Zoltán Horváth,Bálint Szokol,Nóra Breza,Judit Dobos,Csaba Szántai-Kis,Eszter Illyés,Sándor Boros,Robbert Jan Kok,László Őrfi

Bioorganic & Medicinal Chemistry Letters（2018）

引用 6|浏览28

暂无评分

摘要

•62 amino acid substituted sunitinib analogues were synthesized, inhibiting FLT3-ITD kinase and AML cell line.•Physical-chemical properties (solubility, acidity and liphophilicity) were determined for the compounds at pH = 7.4 and 5.5.•Compound 20a was selected to be conjugated with peptide based delivery systems.

查看译文

关键词

FLT3-ITD kinase inhibitior,Acute myeloid leukemia,Chromatographic Hydrophobicity Index,Shake-flask partition coefficient determination,Peptide based targeted delivery

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要