Light-up Probe with Aggregation-Induced Emission for Real-Time Bio-orthogonal Tumor Labeling and Image-guided Photodynamic Therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2018)
摘要
Bio-orthogonal tumor labeling is more effective in delivering imaging agents or drugs to a tumor site than active targeting strategy owing to covalent ligation. However, to date, tumor-specific imaging through bio-orthogonal labeling largely relies on body clearance to differentiate target from the intrinsic probe signal owing to the lack of light-up probes for invivo bio-orthogonal labeling. Now the first light-up probe based on a fluorogen with aggregation-induced emission for invivo bio-orthogonal fluorescence turn-on tumor labeling is presented. The probe has low background fluorescence in aqueous media, showing negligible non-specific interaction with normal tissues. Once it reacts with azide groups introduced to tumor cells through metabolic engineering, the probe fluorescence is lightened up very quickly, enabling rapid tumor-specific imaging. The photosensitizing ability was also used to realize effective image-guided photodynamic tumor therapy.
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关键词
aggregation-induced emission,bio-orthogonal labeling,light-up probes,photodynamic therapy
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