"Super Gene Set" Causal Relationship Discovery from Functional Genomics Data.
IEEE/ACM Transactions on Computational Biology and Bioinformatics(2018)
摘要
In this article, we present a computational framework to identify “causal relationships” among super gene sets. For “causal relationships,” we refer to both stimulatory and inhibitory regulatory relationships, regardless of through direct or indirect mechanisms. For super gene sets, we refer to “pathways, annotated lists, and gene signatures,” or PAGs. To identify causal relationships among PAGs, ...
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关键词
Systems biology,Genomics,Bioinformatics,Gene expression
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