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Repeated Testing With the Hypertonic Saline Assay in Mice for Screening of Analgesic Activity.

ANESTHESIA AND ANALGESIA, no. 1.0 (2019): 269-275

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Abstract

BACKGROUND: In vivo animal assays are a cornerstone of preclinical pain research. An optimal stimulus for determining the activity of potential analgesics would produce responses of a consistent magnitude on repeated testing. Intraplantar (i.pl.) injection of hypertonic saline (HS) in mice produces robust nociceptive responses to differen...More

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