Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension

The American Journal of Human Genetics, pp. 276-287, 2018.

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Abstract:

Primary hypertension is a major risk factor for ischemic heart disease, stroke, and chronic kidney disease. Insights obtained from the study of rare Mendelian forms of hypertension have been invaluable in elucidating the mechanisms causing primary hypertension and development of antihypertensive therapies. Endothelial cells play a key rol...More

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