Clonal Relatedness in Tumour Pairs of Breast Cancer Patients.
Breast cancer research(2018)
摘要
Molecular classification of tumour clonality is currently not evaluated in multiple invasive breast carcinomas, despite evidence suggesting common clonal origins. There is no consensus about which type of data (e.g. copy number, mutation, histology) and especially which statistical method is most suitable to distinguish clonal recurrences from independent primary tumours.
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关键词
Tumour clonality,Bilateral breast cancer,Ipsilateral breast cancer,Intertumour heterogeneity,Similarity index,Multiple breast cancer
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