Evaluation of long-term antiepileptic drug use in patients with temporal lobe epilepsy: Assessment of risk factors for drug resistance and polypharmacy.

•Drug resistance and polypharmacy are common in temporal lobe epilepsy.•Poor effect on initial pharmacotherapy is an early risk factor of drug resistance.•Long disease duration increases the risk of drug resistance and polypharmacy.•2nd generation antiepileptic drugs provide no additional effect.