Mivacurium induce mast cell activation and pseudo-allergic reactions via MAS-related G protein coupled receptor-X2

Delu Che,Jue Wang,Yuanyuan Ding,Rui Liu,Jiao Cao,Yongjing Zhang,Yajing Hou,Hongli An,Zijun Gao,Tao Zhang

Cellular Immunology（2018）

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摘要

•Mivacurium induces mast cell degranulation in a dose-dependent manner.•Mivacurium induced anaphylactoid reactions in mice via Mrgprb2.•Mivacurium induced the release of pro-synthetic inflammatory molecules.•MRGPRX2 mediated the mivacurium-induced mast cell activation.•MRGPRX2 mediates mivacurium-triggered calcium mobilization during anaphylactic reactions by activating PLC-γ and IP3R.

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关键词

Mivacurium,Pseudo-allergic reactions,LAD2 mast cell,MRGPRX2,Cytokine

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