Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis.

Sini Skarp,Olli-Pekka Kämäräinen,Gong-Hong Wei,Eveliina Jakkula,Ilkka Kiviranta,Heikki Kröger,Juha Auvinen,Petri Lehenkari,Leena Ala-Kokko,Minna Männikkö

EUROPEAN JOURNAL OF HUMAN GENETICS（2019）

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摘要

The identified variants revealed novel candidate genes for OA. OLIG3 and FIP1L1 have specific roles in transcription and may effect expression of other genes. Identified variants in these genes may thus have a role in the regulatory events leading to OA.

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