Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke

Alberto Oviedo,Stefan Lebrun,Ulrike Kogel,Jenny Ho,Wei Teck Tan,Bjoern Titz,Patrice Leroy,Gregory Vuillaume, Monali Bera,Florian Martin, Gregory Rodrigo,Marco Esposito,Ruth Dempsey,Nikolai V. Ivanov,Julia Hoeng,Manuel C. Peitsch,Patrick Vanscheeuwijck

Regulatory Toxicology and Pharmacology（2016）

引用 50|浏览8

暂无评分

摘要

The toxicity of a mentholated version of the Tobacco Heating System (THS2.2M), a candidate modified risk tobacco product (MRTP), was characterized in a 90-day OECD inhalation study. Differential gene and protein expression analysis of nasal epithelium and lung tissue was also performed to record exposure effects at the molecular level.

查看译文

关键词

Inhalation,Potential reduced risk product,Heat-not-burn,Pulmonary inflammation,Toxicity,Menthol

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要