1,25-Dihydroxyvitamin D 3 modulates the effects of sublethal BPA on mitochondrial function via activating PI3K-Akt pathway and 17β-estradiol secretion in rat granulosa cells.

Ching-Tien Lee,Jiz-Yuh Wang,Kuang-Yi Chou,Ming-I Hsu

The Journal of Steroid Biochemistry and Molecular Biology（2019）

引用 30|浏览8

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摘要

•1,25D3 increases mtDNA content and attenuates BPA-induced mtDNA deletion.•1,25D3 inhibits BPA-induced decrease in COXI expression and 17β-estradiol secretion.•1,25D3 increases mitochondrial biogenesis-related proteins by PI3K-Akt signalling.•1,25D3 increases ATP production and cellular oxygen consumption rate.

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关键词

1,25D3,Akt,BPA,COX I,COX IV,DMEM,GPx-1,MnSOD,mtDNA,NRF-1,OCR,PGC-1α,PI3K,ROS,Tfam,VDR

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