PLD3 epigenetic changes in the hippocampus of Alzheimer's disease.

Idoia Blanco-Luquin,Miren Altuna,Javier Sánchez-Ruiz de Gordoa,Amaya Urdánoz-Casado,Miren Roldán,María Cámara,Victoria Zelaya,María Elena Erro,Carmen Echavarri,Maite Mendioroz

Clinical epigenetics（2018）

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摘要

PLD3 gene is downregulated in the human hippocampus in AD cases compared to controls. Altered epigenetic mechanisms, such as differential DNA methylation within an alternative promoter of PLD3 gene, may be involved in the pathological processes of AD. Moreover, PLD3 mRNA expression inversely correlates with hippocampal β-amyloid burden, which adds evidence to the hypothesis that PLD3 protein may contribute to AD development by modifying APP processing.

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关键词

APP,Alzheimer’s disease,DNA methylation,Epigenetics,Gene and protein expression,Hippocampus,Lysosome,PLD3

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