Single Agent Efficacy of the HDAC Inhibitor DATS in Preclinical Models of Glioblastoma.
Cancer chemotherapy and pharmacology(2018)
摘要
Glioblastoma (GB) remains incurable despite aggressive chemotherapy, radiotherapy, and surgical interventions; immunotherapies remain experimental in clinical practice. Relevant preclinical models that can accurately predict tumor response to therapy are equally challenging. This study aimed to validate the effect of the naturally occurring agent diallyl trisulfide (DATS) in human GB in relevant pre-clinical models.
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关键词
Glioblastoma,GB,Histone deacetylase inhibitor,Diallyl trisulfide,DATS,PDX: patient-derived orthotopic xenograft
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