ATP Mediates a Negative Autocrine Signal on Stimulus-Secretion Coupling in Mouse Pancreatic Β-Cells.

Cita Bauer,Julia Kaiser,Jelena Sikimic,Peter Krippeit-Drews,Martina Düfer,Gisela Drews

Endocrine（2018）

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摘要

The role of ATP, which is secreted by pancreatic β-cells, is still a matter of debate. It has been postulated that extracellular ATP acts as a positive auto- or paracrine signal in β-cells amplifying insulin secretion. However, there is rising evidence that extracellular ATP may also mediate a negative signal.

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关键词

ATP,P2X receptor,Negative feedback,Calcium,β-cell

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