Simplified and automatable radiochemical separation strategy for the production of radiopharmaceutical quality 86Y using single column extraction chromatography.

Eduardo Aluicio-Sarduy,Reinier Hernandez,Hector F Valdovinos,Christopher J Kutyreff,Paul A Ellison,Todd E Barnhart,Robert J Nickles,Jonathan W Engle

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine（2018）

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摘要

We present a simplified, automatable single-column radiochemical separation method using the extraction chromatographic branched-DGA resin for the production of no-carrier-added 86Y with a radiochemical yield higher than 95%, an apparent molar activity of 1.4 ± 0.4 Ci/μmol (DOTA) and 2.3 ± 0.7 Ci/μmol (DTPA), and a run-to-run recycling efficiency of the isotopically-enriched target of 98 ± 1%. These results enable the preparation of 86Y radiopharmaceuticals for 86Y/90Y-based cancer theranostic applications.

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