Combination Therapy with Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy-a Post-hoc analysis.

Jean-Frédéric Colombel,Omoniyi J Adedokun,Christopher Gasink,Long-Long Gao,Freddy J Cornillie,Geert R D'Haens,Paul J Rutgeerts,Walter Reinisch,William J Sandborn,Stephen B Hanauer

Clinical Gastroenterology and Hepatology（2019）

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摘要

Among patients with CD and similar serum concentrations of infliximab, combination therapy with azathioprine was not significantly more effective than infliximab monotherapy. Combination therapy with azathioprine appears to improve efficacy by increasing pharmacokinetic features of infliximab. ClinicalTrials.gov, NCT00094458.

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关键词

SONIC,Exposure-Response,Serum Infliximab Concentrations,Corticosteroid-Free Clinical Remission,Mucosal Healing

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