The Fast Real-time Assessment of Combination Therapies in Immuno-ONcology (FRACTION) program: innovative, high-throughput clinical screening of immunotherapies.

Katy L Simonsen,Paula M Fracasso,Steven H Bernstein,Megan Wind-Rotolo,Manish Gupta, Adriana Comprelli,Timothy P Reilly,Jim Cassidy

European Journal of Cancer（2018）

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摘要

•The Fast Real-time Assessment of Combination Therapies in Immuno-ONcology (FRACTION) Program is an innovative and adaptive clinical trial program.•FRACTION accelerates access to -I-O therapies for patients with advanced tumours.•FRACTION aims to enhance selection of transformational -I-O combinations.

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关键词

Clinical trial design,FRACTION,Combination immuno-oncology therapy,Platform trial,Nivolumab,Ipilimumab

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