Type-II tRNAs and Evolution of Translation Systems and the Genetic Code.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2018)
摘要
Because tRNA is the core biological intellectual property that was necessary to evolve translation systems, tRNAomes, ribosomes, aminoacyl-tRNA synthetases, and the genetic code, the evolution of tRNA is the core story in evolution of life on earth. We have previously described the evolution of type-I tRNAs. Here, we use the same model to describe the evolution of type-II tRNAs, with expanded V loops. The models are strongly supported by inspection of typical tRNA diagrams, measuring lengths of V loop expansions, and analyzing the homology of V loop sequences to tRNA acceptor stems. Models for tRNA evolution provide a pathway for the inanimate-to-animate transition and for the evolution of translation systems, the genetic code, and cellular life.
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关键词
type-II tRNA,V loop,V loop-acceptor stem homology,minihelices,evolution of tRNA,evolution of translation systems
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