Elucidation of Racemization Process of Azaspirene Skeleton in Neutral Aqueous Media
Journal of Organic Chemistry(2018)
摘要
Azaspirene and related congeners, which possess various biological activities, have a unique spirocyclic core structure. However, there are few studies on the chemical properties of (-)-azaspirene, despite the fact that it may provide important insights into unveiling the biosynthetic pathway. Here, we report a nine-step chemical synthesis of an azaspirene analogue with a new finding that the natural (-)-azaspirene skeleton easily racemizes in neutral aqueous media.
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关键词
Pyrimidine Biosynthesis
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