Genetic Sequence Characterization and Naturally Acquired Immune Response to Plasmodium Vivax Rhoptry Neck Protein 2 (Pvron2).

Najara C. Bittencourt,Juliana A. Leite, Ana Beatriz I. E. Silva, Tamirys S. Pimenta,João Luiz Silva-Filho,Gustavo C. Cassiano,Stefanie C. P. Lopes,Joao C. K. dos-Santos,Catarina Bourgard,Helder I. Nakaya,Ana Maria Revorêdo da Silva Ventura,Marcus V. G. Lacerda,Marcelo U. Ferreira,Ricardo L. D. Machado,Letusa Albrecht,Fabio T. M. Costa

Malaria journal（2018）

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摘要

The genetic diversity of malaria antigens often results in allele variant-specific immunity, imposing a great challenge to vaccine development. Rhoptry Neck Protein 2 (PvRON2) is a blood-stage antigen that plays a key role during the erythrocyte invasion of Plasmodium vivax. This study investigates the genetic diversity of PvRON2 and the naturally acquired immune response to P. vivax isolates.

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关键词

Genetic diversity,RON2,Plasmodium vivax,Immunogenicity,Malaria

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