Chemical Synthesis of 7-Oxygenated 12α-Hydroxy Steroid Derivatives to Enable the Biochemical Characterization of Cytochrome P450 8B1, the Oxysterol 12α-Hydroxylase Enzyme Implicated in Cardiovascular Health and Obesity.

Samuel D Offei,Hadi D Arman, Mirza Oais Baig, Lazaro S Chavez,Carlos A Paladini,Francis K Yoshimoto

Steroids（2018）

引用 9|浏览23

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摘要

•Synthesis of 12α-hydroxy dehydroepiandrosterone derivatives.•Crystal structures for 12β-hydroxy DHEA, 7α-,12α-dihydroxy DHEA, 12α-hydroxy-7-keto DHEA.•Biological activity measured for 7-keto DHEA and 12α-hydroxy-7-keto DHEA.

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关键词

Cytochrome P450 8B1,Organic synthesis,Dehydroepiandrosterone,Cardiovascular health,Obesity,NMDA receptor

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