Inhibitory Effects Of Prunella Vulgaris L. Extract On 11 Beta-Hsd1 In Human Skin Cells
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE(2018)
摘要
Glucocorticoids are a risk factor for age-induced skin structure and function defects, and the glucocorticoid-activating enzyme, 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1), represents a promising therapeutic target. Prunella vulgaris L. ( PV) is a perennial and an edible herbaceous plant normally cultivated in Asia and Europe. A recent study demonstrated a broad range of biological activities of PV including immune modulatory, antiviral, antiallergic, anti-inflammatory, antioxidant, and antidiabetic. However, little is known about the inhibitory effect of PV on 11 beta-HSD1. In this study, we investigated the inhibitory effect of Prunella vulgaris L. extract (PVE) and the underlying mechanism of 11 beta-HSD11 inhibition. Consistent with these results, cortisol levels were also reduced by PVE in vitro. The cortisone-induced translocation of glucocorticoids receptor (GR) was also attenuated. In addition, PVE inhibited a cortisone-mediated decrease in collagen content in skin. Collectively, these results suggest the beneficial effects of PVE in maintaining skin integrity.
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