Dopamine in the hippocampal dentate gyrus modulates spatial learning via D1-like receptors.

•Role of DG-containing DA and D1 receptor in spatial learning and memory is studied in freely moving rats.•The extracellular concentration of DA in the DG is increased during spatial learning process.•Antagonism of D1 receptor in the DG impairs the spatial cognition.•Antagonism of D1 receptor partly inhibits the response of EEAs in the DG during spatial learning.