Histone Demethylase JMJD2D Interacts with Beta-catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice.

Levels of the histone demethylase JMJD2D are increased in human colorectal tumors, compared to non-tumor colon tissues. JMJD2D interacts with beta-catenin to activate transcription of its target genes and promote CRC cell proliferation, migration, and invasion as well as formation of colorectal tumors in mice.