Sanguiin H-11 from Sanguisorbae radix protects HT22 murine hippocampal cells against glutamate-induced death.

Ji Hoon Song,Song-Yi Kim,Gwi Seo Hwang,Youn-Sub Kim,Hyun Young Kim,Ki Sung Kang

Bioorganic & Medicinal Chemistry Letters（2019）

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摘要

•Sanguiin-11 possessed a strong antioxidant activity.•Sanguiin-11 prevented glutamate-induced death in HT22 cells.•Sanguiin-11 inhibited oxidative stress-mediated MAPK activation.

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关键词

Sanguiin H-11 (SH-11),Glutamate,Mitogen-activated protein kinase,Oxidative stress,HT22 cells

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