Expression of pro-inflammatory genes in human endothelial cells: Comparison of rivaroxaban and dabigatran.

Peter Ellinghaus,Elisabeth Perzborn, Peter Hauenschild,Christoph Gerdes,Stefan Heitmeier,Mayken Visser,Holger Summer,Volker Laux

Thrombosis Research（2016）

引用 57|浏览10

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摘要

•Thrombin-induced PAR-1 activation mediates inflammatory gene expression in HUVECs.•Rivaroxaban and dabigatran downregulated the expression of pro-inflammatory markers.•Low concentrations of dabigatran (3–300nM) increased inflammatory gene expression.•Dabigatran at low concentrations showed a transient increase in thrombin activity.

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ACTB,APC,B2M,CXCL,MCP,DMSO,ELAM,EBM,HUVEC,ICAM,IL,MMP,ANOVA,PC,PAR,RFI,TM,TF,TNF,VCAM

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