Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy.

Mohamed I F Shariff,Jin U Kim,Nimzing G Ladep,Mary M E Crossey,Larry K Koomson,Abigail Zabron,Helen Reeves,Matthew Cramp,Stephen Ryder,Shaun Greer,I Jane Cox,Roger Williams,Elaine Holmes,Kathryn Nash,Simon D Taylor-Robinson

Journal of Clinical and Experimental Hepatology（2016）

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摘要

Diagnostic sensitivity was lower than previous African studies, but still outperformed serum AFP. Reduced creatinine, citrate and hippurate and elevated carnitine are comparable with the African studies. p-Cresol sulfate alteration is a novel finding and may indicate an altered sulfonation capacity of the liver in patients with HCC.

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关键词

1H NMR,AFP,ALT,BCLC,BMI,HBV,HCC,HCV,HIV,INR,NASH,PCA,PLS-DA,SEER,STOCSY,TSP,US

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