Polymorphisms and expression of IL-32: impact on genetic susceptibility and clinical outcome of lung cancer.
BIOMARKERS(2017)
摘要
Context: Polymorphisms of IL-32 related closely to tumoregenesis. Materials and methods: Two IL-32 polymorphisms (rs12934561 and rs28372698) and mRNA expression were conducted by SNP genotype assay and real-time PCR in 423 lung cancer patients and 437 controls. Results: T allele of rs28372698 associated significantly with poor prognosis in moderate and well-differentiated lung cancer patients. TT genotype of rs12934561 related closely to poor survival status in squamous carcinoma. IL-32 mRNA expression decreased in lung cancer. Discussion and conclusion: Our study indicates the importance of IL-32 polymorphism and mRNA expression in susceptibility and influence of survival status in lung cancer.
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关键词
32,single-nucleotide polymorphism,lung cancer,prognosis,survival status
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