Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity.

Xi-Ning Cao,Lian-Ju Shen,Sheng-de Wu,Chao Yan,Yue Zhou,Geng Xiong,Yang-Cai Wang,Yang Liu,Bo Liu,Xiang-Liang Tang, Min Guo,Dong-Yao Liu,Chun-Lan Long,Mang Sun,Da-Wei He,Tao Lin,Guang-Hui Wei

Toxicology Letters（2017）

引用 69|浏览10

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摘要

•PM2.5 was exposed to male rats at dose levels of 0, 10, and 20mg/kg.b.w-day.•Major spermatogenesis marker protein expressions reduced after treatment.•SOD activity and expression levels enhanced after treatment.•Sertoli cell oxidative stress and apoptosis were observed after treatment.•Major BTB junction protein expressions reduced after treatment.

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关键词

PM2.5,ROS,NS,Cx43,SOD,BTB,SD,OD,HE,FCS,DCFH-DA,PBS,ZO-1,β-catenin,SDS-PAGE,PVDF,DMC1,Plzf,SCP3,Stra8,GLM

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