Mechanisms involved in antinociception induced by a polysulfated fraction from seaweed Gracilaria cornea in the temporomandibular joint of rats

Chistiane Oliveira Coura,Hellíada Vasconcelos Chaves,Danielle Rocha do Val,Lorena Vasconcelos Vieira,Felipe Dantas Silveira, Fernanda Maxcynne Lino dos Santos Lopes,Francisco Isaac Fernandes Gomes,Annyta Fernandes Frota,Ricardo Basto Souza,Juliana Trindade Clemente-Napimoga,Mirna Marques Bezerra,Norma Maria Barros Benevides

International Journal of Biological Macromolecules（2017）

引用 16|浏览9

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摘要

•A polysulfated fraction isolated from red seaweed Gracilaria cornea (Gc-FI) presents antinociceptive effect in TMJ of Rats.•The antinociceptive effect of Gc-FI is mediated by μ/δ/κ-opioid receptors and activation NO/cGMP/PKG/K+ATP channel pathway.•The present study provides evidence that the antinociceptive effect of Gc-FI requires the integrity of the HO-1 pathway.

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关键词

Seaweed,Sulfated polysaccharide,Antinociception

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