Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway.

Chethan Sampath, Muhammed Raihan Rashid,Shengmin Sang,Mohamed Ahmedna

Food Chemistry（2017）

引用 60|浏览5

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摘要

•Phloretin and [6]-gingerol found in apple and ginger were effective in controlling CML, GSH/GSSG and total AGE levels.•Phloretin and [6]-gingerol influenced expression of RAGE, HO-1, via Nrf2, hypothetically proposing their mechanism of action.•Phloretin and [6]-gingerol clearly show structure–function based activity in eliminating AGEs.

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关键词

Advance glycation end-products,Phloretin,[6]-Gingerol,Nrf2,CML,RAGE,GSH

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