5- lipoxygenase (ALOX5): genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes.

Nojan Nejatian,Ann-Kathrin Häfner,Firouzeh Shoghi,Klaus Badenhoop,Marissa Penna-Martinez

The Journal of Steroid Biochemistry and Molecular Biology（2019）

引用 21|浏览14

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摘要

•ALOX5 rs4987105 polymorphism is associated with T2D.•ALOX5 CC risk genotype is linked to lower vitamin D and increased CRP levels.•IL-1β + calcitriol treatment increased ALOX5, LTA4H and LTB4R1 mRNA expression.•ALOX5 andLTA4H mRNA expression were increased in T2D patients compared to HC.

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关键词

calcitriol,HC,T2D,IL-1β,ALOX5,LTA4H,LTB4R1

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