Cisplatin Resistance Coupled To Enhanced Sensitivity To Metabolic Interventions
MOLECULAR & CELLULAR ONCOLOGY(2018)
摘要
Specific metabolic alterations have recently been observed in cisplatin-resistant cancers. As a result, cisplatin resistance can be overcome by co-administration of pyridoxine, and cisplatin-resistant cancer cells become exquisitely sensitive to killing by inhibitors of poly(ADP-ribose) polymerase, starvation, and antimetabolites targeting nucleotide biosynthesis.
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关键词
chemotherapy, DNA damage response, non-small cell lung cancer
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