Homeobox B13 G84E Mutation and Prostate Cancer Risk.

Tommy Nyberg,Koveela Govindasami,Goska Leslie,Tokhir Dadaev,Elizabeth Bancroft,Holly Ni Raghallaigh,Mark N Brook,Nafisa Hussain,Diana Keating,Andrew Lee, Romayne McMahon,Angela Morgan, Andrea Mullen,Andrea Osborne,Reshma Rageevakumar,Zsofia Kote-Jarai,Rosalind Eeles,Antonis C Antoniou

European Urology（2019）

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摘要

Men with a G84E mutation in the HOXB13 gene are at a high risk of developing prostate cancer. The risk is however heterogeneous, and is modified by both family history and birth cohort. Genetic counselling should account for this heterogeneity.

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Genetic risk,HomeoboxB13,Kin-cohort study,Meta-analysis,Prostate cancer

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