The SuprMam1 breast cancer susceptibility locus disrupts the vitamin D/ calcium/ parathyroid hormone pathway and alters bone structure in congenic mice.

Madara Ratnadiwakara,Melissa Rooke,Stephen J Ohms,Hugh J French,Rohan B H Williams,Rachel W Li,Donghai Zhang,Robyn M Lucas,Anneke C Blackburn

The Journal of Steroid Biochemistry and Molecular Biology（2019）

引用 3|浏览20

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摘要

•We have bred C57BL/6 mice carrying BALB/c breast cancer susceptibility genes.•The phenotype includes altered vitamin D / calcium / parathyroid hormone regulation.•Parathyroid hormone levels in serum were altered but 25(OH)D and calcium were not.•Reduced bone density demonstrates functional insufficiency of vitamin D / calcium.•Increased dietary calcium or vitamin D overcame the genetic differences.

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关键词

Vitamin D,Parathyroid hormone,p53,Modifier genes,Breast cancer,Cyp27b1

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