Targeted delivery of nitric oxide via a 'bump-and-hole'-based enzyme-prodrug pair

Dashuai Zhu
Dashuai Zhu
Yueyuan Fan
Yueyuan Fan
Guowei Feng
Guowei Feng
Yongzhen Wei
Yongzhen Wei
He Wang
He Wang
Kang Qin
Kang Qin
Qiang Yang
Qiang Yang

NATURE CHEMICAL BIOLOGY, pp. 151.0-+, 2019.

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Abstract:

The spatiotemporal generation of nitric oxide (NO), a versatile endogenous messenger, is precisely controlled. Despite its therapeutic potential for a wide range of diseases, NO-based therapies are limited clinically due to a lack of effective strategies for precisely delivering NO to a specific site. In the present study, we developed a ...More

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