Novel 8-aminoquinolines containing an aminoxyalkyl side chain exert in vitro dual-stage antiplasmodial activity.
CHEMMEDCHEM(2019)
摘要
A series of novel 8-aminoquinolines (8-AQs) with an aminoxyalkyl side chain were synthesized and evaluated for in vitro antiplasmodial properties against asexual blood stages, liver stages, and sexual stages of Plasmodium falciparum. 8-AQs bearing 2-alkoxy and 5-phenoxy substituents on the quinoline ring system were found to be the most promising compounds under study, exhibiting potent blood schizontocidal and moderate tissue schizontocidal in vitro activity.
更多查看译文
关键词
8-aminoquinolines,antimalarials,dual-stage antiplasmodial activity,malaria
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要