Integrated analysis of microRNA-mRNA expression in A549 cells infected with influenza A viruses (IAVs) from different host species.

•It is the first integrated analysis of miRNA-mRNA expression in A549 cells infected with IAVs from different host species.•Twenty miRNAs and 1286 mRNAs were differentially expressed in all three infected groups.•A GO enrichment analysis showed that 107 miRNA-mRNA interactions were correlated with the defense of the virus.•A KEGG enrichment analysis showed that 79 miRNA-mRNA interactions were involved in the influenza A reference pathway.