Photodynamic Antimicrobial Chemotherapy (PACT), using Toluidine blue (TBO) inhibits both growth and dimorphism in Paracoccidioides brasiliensis by a mechanism involving reactive Oxygen species (ROS) production.

Juliene Cristina da Silva Passos,Moisés Lopes Carvalho,Flavia Villaça Morais,Maricilia Silva Costa

Photodiagnosis and Photodynamic Therapy（2019）

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摘要

•Photodynamic Antimicrobial Chemotherapy (PACT) can decrease growth of yeast.•The transition from mycelium to yeast form can be inhibited by PACT.•PACT can decrease growth of P. brasiliensis in its mycelial form.

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关键词

Paracoccidioides brasiliensis,Toluidine blue,Fungus,Dimorphism,Photodynamic antimicrobial chemotherapy

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