Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron.

Staci L Haney,Michelle L Varney,Hannah R Safranek,Yashpal S Chhonker,Narendran G-Dayanandan,Geoffrey Talmon,Daryl J Murry,Andrew J Wiemer,Dennis L Wright,Sarah A Holstein

Leukemia Research（2019）

引用 5|浏览20

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摘要

•Iron prevents induction of myeloma cell death by the novel tropolone MO-OH-Nap.•Iron prevents MO-OH-Nap induction of the unfolded protein response (UPR) pathway.•The iron chelator deferoxamine induces upregulation of the UPR in myeloma cells.•MO-OH-Nap directly chelates iron and upregulates transferrin receptor expression.

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关键词

AFS,BCA,CM-H2DCFDA,CI,DFO,ER,FC,HDAC,MM,PI,ROS,SAHA,TFR1,UPR

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