Calcium oscillation and phosphatidylinositol 3-kinase positively regulate integrin αIIbβ3-mediated outside-in signaling

Journal of Biomedical Science, pp. 321-333,

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Keywords:
calcium oscillationintegrin αIIbβ3integrin outside-in signalingphosphatidylinositol 3-kinase

Abstract:

The frequency of calcium oscillation reveals the platelet activation status, however, the biological significance of the periodic calcium responses and methods of communication with other integrin-mediated signals are not clear. RGD-containing disintegrin rhodostomin coated substrates were employed to enhance platelet spreading and calciu...More

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