Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis.

Enze Li,Yi Sun,Guixiang Lv,Yongning Li,Zhiguo Zhang,Zheng Hu,Wenwu Cao

The International Journal of Biochemistry & Cell Biology（2019）

引用 39|浏览9

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摘要

•DVDMS-SDT inhibits Hep-G2 cells proliferation and tumor growth in vitro and in vivo.•DVDMS-SDT induces Hep-G2 cell cycle blocking in the G2/M phase.•DVDMS-SDT activates the p53-caspase-3 pathway of apoptosis via the increased ROS level.

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关键词

DVDMS,US,SDT,DVDMS-SDT,PpIX,ROS,NAC,DCFH-DA,CDK1,p21,BCL2,BAX,p53

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