The role of atenolol in the modulation of the expression of genes encoding pro- (caspase-1) and anti- (Bcl2L1) apoptotic proteins in endothelial cells exposed to intestinal ischemia and reperfusion in rats.

Murched Omar Taha, Thaís de Melo Alexandre E Silva, Keimy Saori Ota, Wander Junqueira Vilela,Ricardo Santos Simões, Alberto Starzewski Junior,Djalma José Fagundes

Acta cirurgica brasileira（2018）

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摘要

Atenolol presents antiapoptotic effects on rat intestine subjected to IR partly by the up-regulation of the anti-apoptotic Bcl2L1 gene expression. Moreover, atenolol can mitigate the pro-apoptotic and pro-inflammatory effects of Casp1 gene on rat intestine after IR.

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关键词

Mesenteric Ischemia,Atenolol,Gene Expression,Ischemia,Reperfusion,Apoptosis,Rats

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