Characterization of native-like HIV-1 gp140 glycoprotein expressed in insect cells.
Vaccine(2019)
摘要
•The deletion of v-cath/chiA gene enhances HIV gp140 expression yield in insect cell.•gp140 mimicked the native-like trimer and adopted distinctive glycosylation pattern.•The native-like Env proteins elicited cross-clade neutralizing antibody in mice.•The alternative gp140 production way might benefit for HIV vaccine development.
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关键词
HIV-1,Envelope glycoprotein,Native-like trimer,Vaccine,Insect cell
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