Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?
Neuropharmacology(2019)
摘要
•Migraine originating from meninges is characterized by pulsating pain and mechanical allodynia.•Piezo receptors expressed in meninges can be activated by mechanical or chemical stimuli such as Yoda1.•Stimulation of Piezo receptors activates trigeminal neurons and triggers the release of CGRP.•Cluster spike analysis revealed expression of Piezo1 receptors in nociceptive fibers of the trigeminal nerve.•Piezo receptors can be involved in generation of migraine pain.
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关键词
Piezo receptors,Yoda1,Trigeminal ganglion,Migraine,Pain
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